Product Safety

FORDAYS QUALITY

Product Safety

Fordays Product Safety Overview

Fordays' primary supplements, including the Natural DN Collagen, are routinely subjected to comprehensive testing protocols to assess toxicity and radioactivity and thus ensure their safety for human consumption.

All cosmetic products undergo human patch tests and allergy tests to ensure safety.

Natural DN Collagen

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No.1-24, August 10, 1993, New Drug No. 88)
Results	LD50>20mL/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

4-week repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>10mL/kg/day No fatalities, abnormalities, and weight abnormalities. No abnormal findings were observed by hematological examination, histological examination, etc., and no toxicity was shown.

Umu Test (Presence or absence of DNA damage)

Testing Body	Food and Drug Safety Center
Safety rules regarding the use of genetically modified organisms, etc.	"Act on Ensuring Biodiversity by Regulation of Genetically Modified Organisms" (June 18, 2003, Act No. 97) "Safety Management Regulations on the Use of Genetically Modified Organisms, etc., Food and Drug Safety Center" (April 1, 2019) (Approval number: R2020-02A) "Safety Management Regulations on the Use of Genetically Modified Organisms, etc., Food and Drug Safety Center" (April 1, 2019) (Approval number: R2020-02A)
Results	Not DNA damaging (negative)

Radioactivity analysis results

We regularly strive to ensure product safety with our well-established quality control system. Since the Great East Japan Earthquake, we report on confirmations of radioactive substances at the raw material supply destinations to provide further safety and assurance to our customers.

Pesticide Residue analysis results

Fcore-2021 (salmon milt extract containing DNA)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>20mL/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

4-week repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>10mL/kg/day No fatalities, abnormalities, and weight abnormalities. No abnormal findings were observed by hematological examination, histological examination, etc., and no toxicity was shown.

Umu Test (Presence or absence of DNA damage)

Testing Body	Food and Drug Safety Center
Safety rules regarding the use of genetically modified organisms, etc.	"Act on Ensuring Biodiversity by Regulation of Genetically Modified Organisms" (June 18, 2003, Act No. 97) "Safety Management Regulations on the Use of Genetically Modified Organisms, etc., Food and Drug Safety Center" (April 1, 2019) (Approval number: R2020-02A)
Results	Not DNA damaging (negative)

FCore-R2023 (Torula yeast extract containing RNA)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Toxicity test guidelines [1] Single-dose toxicity study [September 11, 1989, Drug Trial No. 1-24, August 10, 1993, New Drug No. 88]
Results	LD50>2,000mg/kg The test substance administration did not result in any deaths or abnormalities in body weight or condition. Furthermore, no abnormalities were found during the pathological autopsy. This test demonstrated the absence of acute toxicity in rats.

28-day repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>1,000mg/kg/day The test substance administration did not result in any deaths or abnormalities in body weight or condition. Furthermore, no abnormalities were found during the pathological autopsy. This test demonstrated the absence of acute toxicity in rats.

Bacterial Reverse Mutation Test (Ames test)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"OECD Chemical Substances Testing Guideline 471, Bacterial Reverse Mutation Test" (OECD TG 471, June 26, 2020)
Results	Negative (This substance does not induce genetic mutations.)

Aren SP

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

4-week repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>1,000mg/kg/day No fatalities, abnormalities, and weight abnormalities. No abnormal findings were observed by hematological examination, histological examination, etc., and no toxicity was shown.

Reversion Test (Ames Test)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidance on Genetic Toxicity Testing and Interpretation of Pharmaceuticals" (September 20, 2012, Pharmaceutical and Food Safety Examination No. 0920 No.2) "OECD Guidelines for the Testing of Chemical Substances 471, Reversion Mutation Testing Using Bacteria" (OECD TG 471, July 21 1997)
Results	Negative (No gene mutagenesis detected)

Immuno Vital HI

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

4-week repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>1,000mg/kg/day No fatalities, abnormalities, and weight abnormalities. No abnormal findings were observed by hematological examination, histological examination, etc., and no toxicity was shown.

Red DHA

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

Fiber Mix Bio (Food with Function Claims)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

4-week repeated oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	"Guidelines for Designation of Food Additives and Revision of Usage Standards" (March 22, 1996 No. 29)
Results	NOAEL>1,000mg/kg/day No fatalities, abnormalities, and weight abnormalities. No abnormal findings were observed by hematological examination, histological examination, etc., and no toxicity was shown.

Good Night (Food with Function Claims)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

J Charge (Food with Function Claims)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

Kioku no Kiwami (Food with Function Claims)

Test Type: Toxicity Test

Single dose oral toxicity test (rat)

Testing Body	Food and Drug Safety Center
Guidelines/Testing Method	Drug toxicity test method guidelines [1] Single-dose toxicity study (September 11, 1989, Drug Trial No. 24, August 10, 1993, New Drug No. 88)
Results	LD50>2,000mg/kg No fatalities, abnormalities, and weight abnormalities detected. No abnormal findings were observed by pathological autopsy and no acute toxicities were shown.

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